Artemether

Chemical Structure / Formula of Artemether

  • Formula: C₁₆H₂₆O₅
  • Structure: Similar to artesunate, but more lipophilic, allowing for better CNS penetration.

Artemether

Mechanism of Action

  • Free radical generation via endoperoxide bridge cleavage, leading to parasite destruction.

Uses of Artemether

  • Severe malaria treatment in ACTs.
  • Often combined with Lumefantrine (Coartem®).

Side Effects

  • Neurotoxicity at high doses, nausea, QT prolongation.

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