Artesunate

Chemical Structure / Formula of Artesunate

  • Formula: C₁₉H₂₈O₈
  • Structure: A semisynthetic derivative of artemisinin, containing a lactone endoperoxide bridge.

Artesunate

Mechanism of Action

  • Produces free radicals by reacting with iron in Plasmodium-infected RBCs, leading to parasite death.

Uses of Artesunate

  • First-line treatment for severe malaria ( falciparum).
  • Used in artemisinin-based combination therapy (ACTs).

Side Effects

  • Transient neutropenia, dizziness, nausea.
  • Hemolysis in some patients (post-treatment hemolysis syndrome).

Click Here to Watch the Best Pharma Videos

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.