Didanosine (ddI)

Chemical Structure / Formula of Didanosine (ddI)

  • Formula: C₁₀H₁₂N₄O₃
  • Structure: A purine nucleoside analog (dideoxyinosine) lacking a 3′-OH group.

Didanosine (ddI)

Mechanism of Action

  • Converted into Didanosine triphosphate, which inhibits HIV reverse transcriptase.
  • Causes chain termination due to lack of 3′-OH group.

Uses of Didanosine (ddI)

  • HIV/AIDS therapy (HAART regimen).

Side Effects

  • Pancreatitis (dose-dependent, severe).
  • Peripheral neuropathy, lactic acidosis.
  • Hepatotoxicity, diarrhea.

Click Here to Watch the Best Pharma Videos

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.