Mebendazole (MBZ)

Chemical Structure / Formula of Mebendazole (MBZ)

  • Formula: C₁₆H₁₃N₃O₃
  • Structure: Benzimidazole derivative with carbamate (-NHCOO-) group.

Mebendazole (MBZ)

Mechanism of Action

  • Binds to β-tubulin, preventing microtubule formation, leading to worm paralysis and death.

Uses of Mebendazole (MBZ)

  • Broad-spectrum anthelmintic for ascariasis, trichuriasis, hookworm, enterobiasis (pinworm), strongyloidiasis.

Side Effects

  • GI discomfort, hepatotoxicity.
  • Bone marrow suppression (rare, high doses).

Structure-Activity Relationship (SAR) of Mebendazole

Structural Feature SAR Insight
Benzimidazole nucleus Essential for binding to β-tubulin, inhibiting microtubule polymerization.
Carbamate group at position 2 Crucial for anthelmintic activity.
Aromatic substituents Enhance potency and spectrum.
Side chains (e.g., benzoyl) Affect selectivity and absorption.

Synthesis of Mebendazole

Synthesis of Mebendazole

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