Primaquine Phosphate

Chemical Structure / Formula of Primaquine Phosphate

  • Formula: C₁₅H₂₁N₃O · H₃PO₄
  • Structure: 8-Aminoquinoline

Primaquine Phosphate

Mechanism of Action

  • Disrupts mitochondrial electron transport and generates reactive oxygen species (ROS), killing liver-stage (hypnozoites) and gametocytes of Plasmodium.

Uses of Primaquine Phosphate

  • Radical cure of P. vivax and P. ovale malaria (eradicates hypnozoites).
  • Prevents transmission (gametocidal effect).

Side Effects

  • Hemolysis in G6PD deficiency.
  • Methemoglobinemia, GI distress.

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