Amodiaquine

Chemical Structure / Formula of Amodiaquine

  • Formula: C₂₀H₂₂ClN₃O
  • Structure: A 4-aminoquinoline similar to chloroquine but with a hydroxy aniline

Amodiaquine

Mechanism of Action

  • Similar to chloroquine: heme polymerase inhibition and accumulation of toxic heme.

Uses of Amodiaquine

  • Treatment of chloroquine-resistant malaria ( falciparum).
  • Combination therapy (e.g., Artesunate-Amodiaquine).

Side Effects

  • Agranulocytosis and hepatotoxicity (rare but severe).
  • GI disturbances, pruritus, QT prolongation.

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