Quinacrine Hydrochloride

Chemical Structure / Formula of Quinacrine Hydrochloride

  • Formula: C₂₃H₃₀ClN₃O
  • Structure: Acridine derivative with a chloroquinoline ring.

Quinacrine Hydrochloride

Mechanism of Action

  • Interferes with DNA replication in Plasmodium.

Uses of Quinacrine Hydrochloride

  • Malaria treatment (historical, no longer first-line).
  • Lupus, giardiasis.

Side Effects

  • GI upset, neuropsychiatric symptoms (hallucinations, anxiety).
  • Yellow discoloration of skin and sclera.

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