Sulfacetamide

Chemical Structure / Formula of Sulfacetamide

  • Formula: C8H10N2O3S
  • Structure: Acetamide-containing sulfonamide.

Sulfacetamide

Mechanism of Action

  • Inhibits folic acid synthesis by competing with PABA.

Uses

  • Ophthalmic infections (bacterial conjunctivitis, corneal ulcers).

Side Effects

  • Local irritation, allergic reactions.

Structure-Activity Relationship (SAR)

Structural Feature SAR Insight
Acetamide group Improves water solubility (used in ophthalmic preparations).
Para-amino benzene sulfonamide core Critical for inhibition of dihydropteroate synthase (DHPS) in folate pathway.
Aromatic ring substitutions Usually reduce activity unless they improve solubility without affecting binding.

Synthesis of Sulfacetamide

Synthesis of Sulfacetamide

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