Eflornithine

Chemical Structure / Formula of Eflornithine

  • Formula: C₆H₁₂F₂N₂O₂

Eflornithine

Mechanism of Action

  • Inhibits ornithine decarboxylase, blocking polyamine synthesis, which is essential for Trypanosoma growth.

Uses of Eflornithine

  • Trypanosomiasis (African sleeping sickness: first-line for late-stage disease).

Side Effects

  • Bone marrow suppression (anemia, leukopenia).
  • Seizures, neurotoxicity.

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