Pentamidine Isethionate

Chemical Structure / Formula of Pentamidine Isethionate

  • Formula: C₁₉H₂₄N₄O₂ · C₂H₆O₄S
  • Structure: Aromatic diamidine with an isethionate salt.

Pentamidine Isethionate

Mechanism of Action

  • Binds to DNA and inhibits RNA synthesis in protozoa.
  • Disrupts mitochondrial function.

Uses of Pentamidine Isethionate

  • Pneumocystis jirovecii pneumonia (PCP) in HIV/AIDS patients.
  • Trypanosomiasis (African sleeping sickness).

Side Effects

  • Nephrotoxicity, hypotension, pancreatitis.

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