Tinidazole

Chemical Structure / Formula of Tinidazole

  • Formula: C₈H₁₃N₃O₄S
  • Structure: Nitroimidazole derivative with a sulfur (-S) group.

Tinidazole

Mechanism of Action

  • Prodrug activated under anaerobic conditions by PFOR enzyme.
  • Generates ROS, leading to DNA strand breaks and cell death.

Uses of Tinidazole

  • Similar to Metronidazole but has a longer half-life (used for single-dose treatments).
  • Amoebiasis, giardiasis, trichomoniasis.

Side Effects

  • Metallic taste, nausea, vomiting.
  • Disulfiram-like reaction with alcohol.
  • Peripheral neuropathy (long-term use).

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