Intro to Drug Design & QSAR Approaches Notes [U-5]
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Introduction to Drug Design
- Introduction to Drug Design
- Various Approaches Used in Drug Design
- Physicochemical Parameters Used in QSAR
- Pharmacophore Modeling
- Molecular Docking Techniques
Combinatorial Chemistry
Combinatorial Chemistry: Synthesis Methods
Other Units of Medicinal Chemistry III
Medicinal Chemistry III
Other Subjects of B Pharmacy 6th Semester
Topic wise notes of:
Biopharmaceutics and Pharmacokinetics
- Biopharmaceutics: Absorption & Distribution
- Drug Elimination, Bioavailability & Bioequivalence
- Pharmacokinetics Models, Dosing & Parameters
- Multicompartment models
- Nonlinear Pharmacokinetics
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Topic wise notes of:
Pharmacology III
- Respiratory & GI Tract Drug Pharmacology
- Chemotherapy: Principles & Key Antibiotics
- Chemotherapy: TB, Fungal & Parasitic Drugs
- UTIs, Cancer Chemo & Immunopharmacology
- Toxicology Basics & Chrono pharmacology
Topic wise notes of:
Pharmaceutical Biotechnology
- Introduction to Pharmaceutical Biotechnology
- Genetic Engineering & rDNA Technology
- Immunology and Vaccine Technology
- Microbial Genetics & Biotransformation
- Fermentation & Bioproduct Production
Topic wise notes of:
Pharmaceutical Quality Assurance
- Quality Assurance, GMP, ICH, QbD & Quality System
- GMP: Personnel, Premises & Equipment Control
- Quality Control and Good Laboratory Practice
- Complaints & Document Management
- Calibration and Warehousing
UNITโV: Intro to Drug Design and Related Concepts Notes
1. Drug Design
- Involves designing molecules with desired biological activity.
- Approaches: Structure-based, ligand-based, and prodrug strategies.
2. QSAR (Quantitative StructureโActivity Relationship)
- Links chemical structure to biological activity.
- Key Parameters:
- Log P (lipophilicity)
- Hammettโs ฯ (electronic effects)
- Taftโs Es (steric effects)
- Hansch Analysis (multivariate approach)
3. Pharmacophore Modeling & Docking
- Pharmacophore: Key features needed for activity.
- Docking: Predicts drug binding to targets.
4. Combinatorial Chemistry
- Used to create diverse compound libraries.
- Methods: Solid-phase and solution-phase synthesis
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