Respiratory & GI Tract Drug Pharmacology Notes [U-1]

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Pharmacology of drugs acting on Respiratory system

Drugs used in the management of COPD

Expectorants and antitussives

Nasal Decongestants

Respiratory Stimulants

Pharmacology of drugs acting on the Gastrointestinal Tract

Drugs for constipation and diarrhoea

Appetite stimulants and suppressants

Digestants and carminatives

Emetics and Anti-Emetics

Other Units of Pharmaceutical Quality Assurance

Pharmacology III

Other Subjects of B Pharmacy 6th Semester

Topic wise notes of:

Herbal Drug Technology

Herbal Raw Materials & Indian Medicine Systems
Nutraceuticals: Uses, Herbs & Interactions
Herbal Cosmetics, Excipients & Formulations
Herbal Drug Evaluation, Patents & Regulations
Herbal Industry: Scope, GMP & Infrastructure

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Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

Biopharmaceutics: Absorption & Distribution
Drug Elimination, Bioavailability & Bioequivalence
Pharmacokinetics Models, Dosing & Parameters
Multicompartment models
Nonlinear Pharmacokinetics

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Pharmaceutical Quality Assurance

Quality Assurance, GMP, ICH, QbD & Quality System
GMP: Personnel, Premises & Equipment Control
Quality Control and Good Laboratory Practice
Complaints & Document Management
Calibration and Warehousing

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Topic wise notes of:

Medicinal Chemistry III

Antibiotics & Aminoglycosides
Antibiotics & Antimalarials: Structures & SAR
Anti-TB, UTI & Antiviral Agents
Antifungals, Antiprotozoals & Sulfonamides
Intro to Drug Design & QSAR Approaches

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Topic wise notes of:

Pharmaceutical Biotechnology

Introduction to Pharmaceutical Biotechnology
Genetic Engineering & rDNA Technology
Immunology and Vaccine Technology
Microbial Genetics & Biotransformation
Fermentation & Bioproduct Production

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1. Drugs Acting on Respiratory System

a. Anti-asthmatic drugs

Bronchodilators: β2 agonists (salbutamol), anticholinergics (ipratropium), methylxanthines (theophylline).
Anti-inflammatory: Corticosteroids, leukotriene antagonists, mast cell stabilizers.

b. COPD drugs

Long-acting bronchodilators (LABA, LAMA).
Inhaled corticosteroids (severe cases).
Phosphodiesterase-4 inhibitors.

c. Expectorants & Antitussives

Expectorants: guaifenesin, potassium iodide (increase secretion).
Antitussives: codeine, dextromethorphan (suppress cough reflex).

d. Nasal decongestants

Sympathomimetics (oxymetazoline, pseudoephedrine). Reduce mucosal edema via vasoconstriction.

e. Respiratory stimulants

Doxapram, nikethamide. Act on medullary centers to stimulate breathing.

2. Drugs Acting on Gastrointestinal Tract

a. Antiulcer agents

Antacids, H2 blockers (ranitidine), proton pump inhibitors (omeprazole), cytoprotectives.

b. Constipation & diarrhoea

Laxatives: bulk (psyllium), stimulant (senna).
Antidiarrheals: loperamide, ORS.

c. Appetite regulators

Stimulants: corticosteroids, cyproheptadine.
Suppressants: sibutramine (withdrawn), orlistat.

d. Digestants & carminatives

Digestants: enzymes (pepsin, pancreatin).
Carminatives: peppermint oil, relieve flatulence.

e. Emetics & antiemetics

Emetics: apomorphine, ipecac.
Antiemetics: ondansetron (5-HT3 blocker), metoclopramide, antihistamines

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